FLUORESCENT FOCUS SIZE REDUCTION BY SPLEEN CELLS OF MICE IMMUNIZED WITH RABIES VIRUS

Fluorescent Focus Size Reduction by Spleen Cells of Mice Immunized with Rabies Virus

The spread of rabies virus between adjacent mouse neuroblastoma cells was inhibited in the presence of spleen cells from mice sensitized to rabies virus as measured by the size of fluorescent focus formation. This activity of focus size reduction was appeared to be closely related to the deVelopment of cell-mediated cytotoxic activity. Rabies virus inactivated by beta-propiolactone was also cap...

Cytochemical studies with African Horse-Sickness Virus by Fluorescent Microscopy

Enhancement of spleen focus formation and virus replication in Friend virus-infected mice.

Spleen focus formation, induced by a member [spleen focus forming virus (SFFV)] of the Friend virus complex, was en hanced in mice that had been infected 2 days previously with Newcastle disease virus or lactic dehydrogenase-elevating virus. Enhancement was also observed in mice treated with erythro poietin or maintained in 10 percent oxygen for 48 hours be fore SFFV infection. Sublethally irra...

Visualization of Horse Sickness virus by the Fluorescent antibody technique

Cancer Therapy: Preclinical Spleen Cells from Young but Not Old Immunized Mice Eradicate Large Established Cancers

Purpose: Solid tumors that have grown twoweeks or longer inmice and have diameters larger than 1 cm are histologically indistinguishable from autochthonous human cancers. When experimental tumors reach this clinically relevant size, they are usually refractory to most immunotherapies but may be destroyed by adoptive T-cell transfer. However, TCR-transgenic T cells and/or tumor cells overexpress...